40 to 50 % of animals that are affected by this condition are diagnosed with an idiopathic form of the problem. How Supplied: Nasophrin ®Nasal drops are available as 0.25% & 0.5% solutions in 10 mL plastic bottles … Data sources include IBM Watson Micromedex (updated 2 Feb 2021), Cerner Multum™ (updated 3 Feb 2021), ASHP (updated 29 Jan 2021) and others. Eye pain and stinging on instillation, temporary blurred vision and photophobia, and conjunctival sensitization may occur. Maximal mydriasis occurs in 20 to 90 minutes with recovery after 3 to 8 hours. This is not a complete description of all coverage terms, conditions, and limitations; see your plan for a full description. Phosphoric Acid and/or Sodium Hydroxide may be added to adjust pH (4.0 to 7.5). Phenylephrine hydrochloride ophthalmic solution, USP 10% is a clear, colorless, sterile topical ophthalmic solution containing phenylephrine hydrochloride 10%. It may also cause headache, anxiety, nausea, and vomiting, and ventricular arrhythmias. Objective To evaluate the effect of topical ophthalmic 10% phenylephrine on systolic arterial pressure (SAP), diastolic arterial pressure (DAP), mean arterial pressure (MAP), pulse rate (PR) and electrocardiogram (ECG) in dogs.. Clear, colourless, sterile eye drops containing Phenylephrine Hydrochloride Ph. ... Phenylephrine … Your veterinarian can help the condition temporarily however, by prescribing phenylephrine eye drops to be used two to three times per day. As a result, your pet's pupil constricts and the muscles surrounding the eye relax. Dosage Form: ophthalmic solution. To avoid contamination, do not touch the dropper tip or let it touch your eye or any other surface. The solution has a tonicity of 985 mOsm/kg; PRESERVATIVE: Benzalkonium Chloride 0.1 mg (0.01%). After this time there is a greater risk that the drops may become contaminated and cause an eye infection. If it is determined that your pet has idiopathic Horner's syndrome, it will typically recover on its own in about three to four months. At these moments when your pet is ill or maybe needs surgery, you want to be protected for the unexpected and high veterinarian costs. Each mL of Phenylephrine Hydrochloride Ophthalmic Solution, USP 2.5% contains: ACTIVE: Phenylephrine Hydrochloride 25 mg (2.5%); INACTIVES: Sodium Phosphate Monobasic, Sodium Phosphate Dibasic, Water for Injection. Once your veterinarian has treated the cause, phenylephrine eye drops are recommended to relieve clinical symptoms of the eye. For the full list of excipients, see section 6.1. When adding a dog or cat to your family you want to make sure your pet is happy, healthy and protected. Not for Phosphoric Acid and/or Sodium Hydroxide may be added to adjust pH (4.0 to 7.5). Phenylephrine 1% was prepared on each examination day by diluting phenylephrine 10% hydrochloride (0.1 ml) with 0.9 ml of preservative free natural tear drops. Advise patients not to touch the dropper tip to any surface as this may contaminate the solution. Use these dosage charts for infants and children under 12 years old: epinephrine, atropine ophthalmic, brimonidine ophthalmic, phenylephrine ophthalmic, EpiPen, Adrenalin, oxymetazoline ophthalmic, fluorometholone ophthalmic. A significant elevation in blood pressure is not common but has been reported following conjunctival instillation of recommended doses of phenylephrine 10%. Overdosage of phenylephrine may cause a rapid rise in blood pressure. Discounts are subject to eligibility requirements. Select one or more newsletters to continue. The post-treatment blood pressure of patients with cardiac and endocrine diseases and any patients who develop symptoms should be carefully monitored. The clinician interpreting each … Medically reviewed by Drugs.com. No overall differences in safety and effectiveness have been observed between elderly and younger adult patients. The solution has a tonicity of 340 mOsm/kg; PRESERVATIVE: Benzalkonium Chloride 0.1 mg (0.01%). WebMD provides common contraindications for Phenylephrine Ophthalmic (Eye). Phenylephrine Hydrochloride Ophthalmic Solution, USP 2.5% is supplied as a sterile, aqueous, topical ophthalmic solution in an opaque, white low density polyethylene (LDPE) bottle with a natural LDPE dropper tip and red cap in the following sizes: NDC 17478-201-02 2 mL in 6 cc bottle This may involve antibiotics, sutures, surgery or a wide variety of other treatments depending on the problem. NDC 17478-201-15 15 mL in 15 cc bottle. Phenylephrine Hydrochloride Ophthalmic Solution, USP 10% is supplied as a sterile, aqueous, topical ophthalmic solution in an opaque, white low density polyethylene (LDPE) bottle with a natural LDPE dropper tip and red cap in the following sizes: NDC 17478-206-05 5 mL in 10 cc bottle. The systemic exposure following topical administration of phenylephrine hydrochloride ophthalmic solution has not been studied. A higher systemic absorption is expected for the 10% solution than the 2.5% solution and when the corneal barrier function is compromised. Dog Veterinarian: DrJessicaO , Veterinarian replied 8 years ago Yes, but again, this … Each carton contains 20 single dose units. Phenylephrine hydrochloride is an α-1 adrenergic agonist drug that is used in ophthalmology mainly for its mydriatic effect. After topical application to the conjunctiva, phenylephrine acts directly on α-adrenergic receptors in the eye, producing contraction of the dilator muscle of the pupil and constriction of the arterioles in the conjunctiva. Rebound miosis has been reported one day after receiving phenylephrine hydrochloride ophthalmic solution, and re-instillation of the drug produced a lesser mydriatic effect. If the eye does not respond to the eye drops… Horner's syndrome is a common neurological disorder of the eye and facial muscles and can occur suddenly. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. A phenylephrine solution eye drop will be put in both eyes of your dog. Symptomatic treatment may include phenylephrine drops placed in the affected eye every 12-24 hours." If a child accidentally swallows these eye drops or nasal decongestant spray, call the toll-free Poison Help Line (1-800-222-1222) and seek emergency medical care immediately. Since horner's syndrome can also occur due to injuries or illness, any breed of dog, cat or horse can be affected. Copyright 2016-2021 PetPremium Inc. All rights reserved. PREDNEFRIN®FORTE eye drops contain prednisolone acetate (microfine suspension) 10 mg (1%), phenylephrine hydrochloride 1.2 mg (0.12%), benzalkonium chloride 0.04 mg (0.004%) per 1 mL, with hypromellose, phenazone, polysorbate 80, boric acid, sodium citrate, sodium metabisulfite, sodium chloride, disodium edetate … After opening, Phenylephrine Hydrochloride Ophthalmic Solution, USP can be used until the expiration date on the bottle. Eye. There are several symptoms of Horner's syndrome that you can look for, and they typically occur on the side of the face that has been injured. Not for Treatment is not required, but phenylephrine eye drops may resolve the clinical signs. It is indicated for some diagnostic eye examinations, such as diagnosing Horner's syndrome Horner's syndrome. Cardiovascular effects which have been seen primarily in hypertensive patients following topical ocular use of phenylephrine hydrochloride ophthalmic solution 10% include marked increase in blood pressure, syncope, myocardial infarction, tachycardia, arrhythmia and subarachnoid hemorrhage [See Warnings and Precautions (5.2 and 5.3)]. Phenylephrine hydrochloride ophthalmic solution 10% is contraindicated in patients with hypertension or thyrotoxicosis. The following serious adverse reactions are described below and elsewhere in the labeling: The following adverse reactions have been identified following use of phenylephrine hydrochloride ophthalmic solution. 2 or 3 drops of a 0.25 to 0.5% solution into each nostril every three to four hours as needed. Dealing with any underlying disease is critical. Each mL of Phenylephrine Hydrochloride Ophthalmic Solution, USP 10% contains: ACTIVE: Phenylephrine Hydrochloride 100 mg (10%); INACTIVES: Sodium Phosphate Monobasic, Sodium Phosphate Dibasic, Water for Injection. However, the following breeds of canines are most vulnerable to Horner's Syndrome: Golden Retrievers and Cocker Spaniels. Pupil dilation is performed during some portions of an eye … Phenylephrine hydrochloride ophthalmic solution 10% is contraindicated in pediatric patients less than 1 year of age [See Contraindications (4.2)]. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Manufactured by: Akorn, Inc. Lake Forest, IL 60045. Caution should be exercised with the use of phenylephrine 10% in pediatric patients less than 5 years of age and patients with hyperthyroidism, or cardiovascular disease. During its lifetime your pet is exposed to many illnesses and diseases and some breeds are affected by a congenital disease which is a condition existing at birth. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. If your dog or cat's condition is … In pediatric patients less than 1 year of age, one drop of phenylephrine hydrochloride ophthalmic solution 2.5% should be instilled at 3 to 5 minute intervals up to a maximum of 3 drops per eye. Phenylephrine HCl, commonly known as Ak-Dilate® or Ak-Nephrin®, is an agent used to dilate the pupil in dogs and cats. When accidentally ingested by dogs … Find out what health conditions may be a health risk when taken with Phenylephrine Ophthalmic (Eye) Cookie notice. However, if your pet's condition is idiopathic, it can occur on either side. 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